-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative Bacilli
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چکیده
-Lactam and Fluoroquinolone Combination Antibiotic Therapy for Bacteremia Caused by Gram-Negative Bacilli Majdi N. Al-Hasan,* John W. Wilson, Brian D. Lahr, Kristine M. Thomsen, Jeanette E. Eckel-Passow, Emily A. Vetter, Imad M. Tleyjeh, and Larry M. Baddour Department of Medicine, Division of Infectious Diseases, University of Kentucky, Lexington, Kentucky; Department of Medicine, Division of Infectious Diseases, Department of Health Sciences Research, Division of Biomedical Statistics and Informatics, and Department of Laboratory Medicine and Pathology, Division of Clinical Microbiology, College of Medicine, Mayo Clinic, Rochester, Minnesota; and Research Center, King Fahd Medical City, Riyadh, Saudi Arabia
منابع مشابه
Beta-lactam and fluoroquinolone combination antibiotic therapy for bacteremia caused by gram-negative bacilli.
The role of combination antibiotic therapy with a beta-lactam and a fluoroquinolone for bacteremia caused by gram-negative bacilli, to our knowledge, has not been previously described. Much of the previous study of combination therapy has included beta-lactams and aminoglycosides. We conducted a large retrospective cohort study to evaluate 28-day all-cause mortality in patients with monomicrobi...
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The aim of the present study was to test whether the combination of a beta-lactam drug plus an aminoglycoside has advantage over monotherapy for severe gram-negative infections. Of 2,124 patients with gram-negative bacteremia surveyed prospectively, 670 were given inappropriate empirical antibiotic treatment and the mortality rate in this group was 34%, whereas the mortality rate was 18% for 1,...
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IMPORTANCE Definitive combination antibiotic therapy with a β-lactam and an aminoglycoside for the treatment of gram-negative bacteremia is commonly prescribed in pediatric patients; however, its efficacy and toxicity relative to β-lactam monotherapy are unknown. OBJECTIVE To determine whether definitive combination antibiotic therapy affects mortality and nephrotoxicity in pediatric patients...
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